A geometric morphometric assessment of change in midline brain structural shape following a first episode of schizophrenia.
نویسندگان
چکیده
BACKGROUND Previous reports indicate that brain structural abnormalities may be progressive in some patients with schizophrenia. Our study was designed to determine deviations in the shape of midline brain structures at the time of onset of symptoms of schizophrenia and 3-5 years later. METHODS Eleven landmarks were located on the midsagittal magnetic resonance imagery brain scans of 55 patients with schizophrenia and 22 nonpsychiatric control individuals. Geometric morphometric methods were used for the extraction of shape variables from landmark coordinates. Permutation tests were used to test the effects of gender, diagnosis, time elapsed since illness onset, and age on brain shape. RESULTS The diagnosis-by-time interaction and the effect of gender were significantly different from zero (p<.027 and p <.039, respectively). The effect of time was significant in patients (p <.002), but not in control subjects. Some anatomical abnormalities in mean patient brain morphology seem to be present both at the time of diagnosis and at follow-up. These are similar to anomalies reported by previous geometric morphometrics studies. CONCLUSIONS Some previously identified brain abnormalities are detectable at the time of first hospitalization. The rapid change in midline brain morphology in patients with schizophrenia during the subsequent 3-5 years is consistent with either a neurodegenerative disease process or an effect of treatment with psychiatric drugs. There is a sexual dimorphism in brain morphology that might be reduced by schizophrenia.
منابع مشابه
Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder.
OBJECTIVE The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality. METHOD Corpus callosum area and shape we...
متن کاملAllometric growth pattern and morphological changes of green terror Andinoacara rivulatus (Günther, 1860) (Cichlidae) during early development: Comparison of geometric morphometric and traditional methods
Allometric growth pattern and body shape changes of the Green terror (Andinoacara rivulatus)(Cichlidae) were studied using landmark-based geometric morphometric (GM) and traditional methods, from hatching up to 1266 Hours Post Hatching (HPH) under culture conditions. The left side of specimens were photographed using digital camera and morphometric characters, including total length, head lengt...
متن کاملAllometric growth pattern and morphological changes of green terror Andinoacara rivulatus (Günther, 1860) (Cichlidae) during early development: Comparison of geometric morphometric and traditional methods
Allometric growth pattern and body shape changes of the Green terror (Andinoacara rivulatus)(Cichlidae) were studied using landmark-based geometric morphometric (GM) and traditional methods, from hatching up to 1266 Hours Post Hatching (HPH) under culture conditions. The left side of specimens were photographed using digital camera and morphometric characters, including total length, head lengt...
متن کاملA Comparative Study on Body Shape of the Genus Alburnus (Rafinesque, 1820) in Iran, Using Geometric Morphometric Analysis
Geometric morphometric method was used to examine body shape variations among all the seven valid species of the genus Alburnus in Iran. In total 409 specimens of A. chalcoides, A. filippii, A. atropatenae, A. caeruleus, A. mossulensis, A. hohenackeri and A. zagrosensis were collected from Babolrud, Baleqlu-Chai, Miriseh, Sarabeleh, Gamasiyab, Mahabad-Chai Rivers and the Gandoman lagoon, respec...
متن کاملSize and shape analysis of two close Cyprinidae species (Garra variabilis-Garra rufa) by geometric morphometric methods
In this study, the shape and size differences between 30 samples of Garra rufa and Garra variabilis species captured in Tigris River were investigated by using geometric morphometric methods. According to the results of this study, there is no difference between these two species in terms of size (CS); however, they are quite different from each other in terms of shape and this difference is si...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biological psychiatry
دوره 48 5 شماره
صفحات -
تاریخ انتشار 2000